BUSINESS OVERVIEW 6 Because cel ls expressing optogenetic protein are less light of the transduced RGCs was measured upon light activation at sensitive than normal photoreceptors, vision under regular the appropriate wavelength and at varying intensities. The results daylight conditions is unlikely to be possible. However, amplifying demonstrate that two months post-injection, the RGCs of non- the light source and mimicking the normal retinal activity of human primates are active, and have the ability to transmit visual capturing visual information will then amplify the light signal at the information as normal RGCs would. appropriate wavelength to enable vision restoration. We conducted a confirmatory study in monkeys to assess the Product Structure for GS030 activity of GS030 at various doses and at six months post-injection. GS030 consists of two components: GS030 proof-of-concept in non-human primates • a gene therapy product comprising a gene encoding a at six months post-injection photoactivatable channelrhodopsin protein, ChrimsonR, delivered via a modified AAV2 known as AAV2 7 m8; and • an external wearable device in the form of biomimetic goggles that stimulate the engineered retinal cells. The images are projected by a light source that uses a specific wavelength onto the retina. Development Program of GS030 for the Treatment of RP We have conducted numerous preclinical studies including a local tolerance study in mice and a long-term toxicity and biodistribution study in monkeys. GS030 for the treatment of RP is currently in an ongoing Phase I/I I trial and weexpect to treat the first subject in this orphan family of diseases in the second quarter of 2018. Preclinical Studies of GS030 in Non-Human Primates GS030 was injected intravitreally in both eyes of monkeys. After two months, the retinas were dissected and connected to a multi- electrode array system to record the electrical activity of RGCs. At regular intervals (two months and six months) the firing activity 78 – GENSIGHT BIOLOGICS – 2017 Registration Document