BOARD PRACTICES 16 For the fiscal year ended December 31, 2017, in addition to the information provided in this section, the status of application of the guidelines in the MiddleNext Code is as follows: Recommendations of the MiddleNext Code Adopted Will be adopted I. The sovereign body This Code does not provide any recommendation intended for the shareholders. II. The supervisory body R 1: Ethics for the members of the Board of Directors X R 2: Conflicts of interest X R 3: Composition of the Board – Presence of independent members of the Board X R 4: Information to the members of the Board X R 5: Organization of the meetings of the Board and committees X R 6: Creation of committees X R 7: Implementation of an internal regulation of the Board X R 8: Election of each director X R 9: Term of office of the members of the Board X R 10: Compensation of directors X R 11: Implementation of an assessment of the work of the Board X R 12: Relationship with the “shareholders” X III. The executive body R 13: Definition and transparency of the compensation of senior executives X R 14: Succession plan of senior executives X R 15: Combined employment / corporate office contracts X R 16: Severance compensation X R 17: Supplementary pension schemes X R 18: Stock options and allocation of bonus shares X R 19: Review of points of vigilance X 16.4.2 CODE OF ETHICS (CODE DE DÉONTOLOGIE) • fifteen (15) calendar days preceding the day of publication of Each director shal l refrain from engaging in any transaction our quarterly information if applicable. involving our shares when such director, by virtue of his or her Persons subject to these black-out periods are not permitted to position within the Company, is in possession of material non- trade in our securities until the day after the information has been public information. released. Sale and purchase transactions involving our securities or In any case, the Board of Directors can decide, in the event of a derivatives carried out by our corporate executives and directors material fact that could significantly affects the market price of whether on the open market or in off-market block trading, be it our securities, to set a period during which sale and purchase directly or indirectly, are forbidden during the period of: transactions involving our securities or derivatives carried out by • thirty (30) calendar days preceding the day of publication of our our corporate executives and directors whether on or off-market, half-yearly and annual financial statements; and be it directly or indirectly, will be forbidden. GENSIGHT BIOLOGICS – 2017 Registration Document– 169