RISK FACTORS 4 Risks covered Insurer Amount Excess per claim Employee Travel Insurance CHUBB (N° FRBBBA22378) Death or total permanent invalidity Up to €500 K depending on the person insured Assistance (for individuals and legal Travel incidents: up to €15 K, assistance abroad, business assistance, Legal assistance: up to €20 K travel incident assistance) Medical insurance and luggage and No limitation for medical professional equipment insurance insurance out of the country of residence and €5 K for luggage and professional equipment Civil responsibility Up to €7,500 K Research sponsor’s civil liability insurance Study GS-LHON-CLIN-03A in HDI Gerling mainland France and its overseas departments and territories: • Victim €1,000 K €1,500 per victim capped at €16,000 per protocol • Research protocol €6,000 K • Claims made during an insurance €10,000 K year by one and the same sponsor for several research protocol Study GS-LHON-CLIN 03A in Italy, ALLIANZ U.K. and USA: • ITALY : – Per Victim €1,500 K – Per Research protocol €5,000 K • UNITED KINGDOM – Per Research protocol £5,000 K • UNITED STATES – Per research protocol $5,000 K Study GS-LHON-CLIN-03A ALLIANZ in Germany • Per victim €500 K – i f up to 1,000 patients participate €5,000 K in this trial – i f more than 1,000 patients and up €10,000 K to 3,000 participate in this trial – i f more than 3,000 patients €15,000 K participate in this trial 56 – GENSIGHT BIOLOGICS – 2017 Registration Document